Based on critical review, recommendations for practice are suggested and a future study design is proposed. The purposes of this review article are to provide a brief background on glucosamine and chondroitin use in canine osteoarthritis and to critically review the available literature on the role of these products for improving clinical outcomes. There is a paucity of well-designed clinical veterinary studies investigating the true treatment effect of glucosamine and chondroitin. Despite limited and conflicting evidence, the natural products glucosamine hydrochloride (HCl) and chondroitin sulfate are commonly recommended by veterinarians for treating osteoarthritis in dogs. Pain and decreased mobility resulting from osteoarthritis often have a negative impact on the affected canine’s quality of life, level of comfort, daily functioning, activity, behaviour, and client-pet companionship. Osteoarthritis is a slowly progressive and debilitating disease that affects canines of all breeds.
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